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A Visual Metaphor Describing Neural Dynamics in Schizophrenia
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A Visual Metaphor Describing Neural Dynamics in Schizophreni

dx.plos.org — Nico J. M. van Beveren, Lieuwe de Haan: However, it remains difficult to understand how the characteristic symptoms of schizophrenia such as hallucinations and delusions are related to disturbances on the molecular-biological level. In general, psychiatry seems to lack a conceptual framework with sufficient explanatory power to link the mental- an


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Nico J. M. van Beveren1, Lieuwe de Haan2*

1 Erasmus University Medical Center, Department of Psychiatry, Rotterdam, The Netherlands, 2 Department of Psychiatry, Academic Medical Center/de Meren, Amsterdam, The Netherlands
Abstract Top
Background

In many scientific disciplines the use of a metaphor as an heuristic aid is not uncommon. A well known example in somatic medicine is the ‘defense army metaphor’ used to characterize the immune system. In fact, probably a large part of the everyday work of doctors consists of ‘translating’ scientific and clinical information (i.e. causes of disease, percentage of succes versus risk of side-effects) into information tailored to the needs and capacities of the individual patient. The ability to do so in an effective way is at least partly what makes a clinician a good communicator. Schizophrenia is a severe psychiatric disorder which affects approximately 1% of the population. Over the last two decades a large amount of molecular-biological, imaging and genetic data have been accumulated regarding the biological underpinnings of schizophrenia. However, it remains difficult to understand how the characteristic symptoms of schizophrenia such as hallucinations and delusions are related to disturbances on the molecular-biological level. In general, psychiatry seems to lack a conceptual framework with sufficient explanatory power to link the mental- and molecular-biological domains.
Methodology/Principal Findings

Here, we present an essay-like study in which we propose to use visualized concepts stemming from the theory on dynamical complex systems as a ‘visual metaphor’ to bridge the mental- and molecular-biological domains in schizophrenia. We first describe a computer model of neural information processing; we show how the information processing in this model can be visualized, using concepts from the theory on complex systems. We then describe two computer models which have been used to investigate the primary theory on schizophrenia, the neurodevelopmental model, and show how disturbed information processing in these two computer models can be presented in terms of the visual metaphor previously described. Finally, we describe the effects of dopamine neuromodulation, of which disturbances have been frequently described in schizophrenia, in terms of the same visualized metaphor.
Conclusions/Significance

The conceptual framework and metaphor described offers a heuristic tool to understand the relationship between the mental- and molecular-biological domains in an intuitive way. The concepts we present may serve to facilitate communication between researchers, clinicians and patients.

Citation: van Beveren NJM, de Haan L (2008) A Visual Metaphor Describing Neural Dynamics in Schizophrenia. PLoS ONE 3(7): e2577. doi:10.1371/journal.pone.0002577

Editor: Kenji Hashimoto, Chiba University Center for Forensic Mental Health, Japan

Received: February 19, 2008; Accepted: May 27, 2008; Published: July 9, 2008

Copyright: © 2008 van beveren, De Haan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: The authors have no support or funding to report.

Competing interests: The authors have declared that no competing interests exist.

* E-mail: l.dehaan@amc.uva.nl
http://digg.com/general_sciences/A_Visual_Metaphor_Describing_Neural_Dynamics_in_Schizophreni
środa, 22 kwietnia 2009, kultur

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